Sun Sun


Department of Chemistry & Biochemistry
The University of Texas at Austin
1 University Station A5300
Austin, TX 78712-0165





















Contact Information


Office: WEL: 5.416
Phone: 471-2073

Lab


Office:
Phone:
Fax:

Dionicio R. Siegel


dsiegel@cm.utexas.edu
Assistant Professor, Faculty


Research Group


Siegel Group

Education


BA, Reed College, 1997
PhD, Harvard University, 2003

Research Fellow, Memorial Sloan Kettering Cancer Center 2003-2007

Awards


CDMRP Fellowship Award, 2007
Upjohn-Pharmacia Fellow, 1998


Reaction Development, Natural Product Synthesis, and Medicinal Chemistry


Natural products are the cornerstone of our group. Within the broad study of natural products chemistry there are three primary areas of inquiry; total synthesis, reaction development, and molecular pharmacology. Typical targets selected for total synthesis possess structures that, from a synthetic chemistry point of view, have atom connectively challenges. In addressing these challenges within specific targets, inspiration may be gained for new synthetic methods. Our goal is to develop new methods to compliment and improve upon existing reactions. Accordingly, emphasis is placed on the development of reactions that are generally applicable to synthesis, as it is most broadly defined. The second area of focus and inquiry in our group is the study of natural products that are biologically relevant in selected fields of biology and medicine. Through interdisciplinary collaborations, we will study optimization of the biological performance and/or investigation into the mechanism action of the natural products prepared in our laboratory. Information gained through these collaborations will determine the future direction of the projects undertaken.

Representative Publications



M. G. Charest, D. R. Siegel, A. G. Myers "Synthesis of ( - ) -Tetracycline." J. Am. Chem. Soc. 127 (2005): 8292-8293.

H. Liu, D. R. Siegel, S. J. Danishefsky "Studies Directed Toward the Synthesis of Terreulactone A: Rapid Synthesis of the A, B, C Rings." Org. Lett. 8 (2006): 423-425.

M. G. Charest, C. D. Lerner, J. D. Brubaker, D. R. Siegel, A. G. Myers "A Convergent, Enantioselective Synthetic Route to Structurally Diverse 6-Deoxytetracycline Antibiotics." Science 308 (2005): 395-398.

D. R. Siegel, S. J. Danishefsky "Total Synthesis of Garsubellin A." J. Am. Chem. Soc. 128 (2006): 1048-1049.