Contact InformationOffice: NHB 5.132A
LabOffice: NHB 5.122/5.132
Dionicio R. Siegeldsiegel@cm.utexas.edu
Assistant Professor, Faculty
PhD, Harvard University, 2003
BA, Reed College, 1997
Research Fellow, Memorial Sloan Kettering Cancer Center 2003-2007
National Science Foundation CAREER Award, 2012
College of Natural Sciences Outreach Innovation Award, 2011
Camille and Henry Dreyfus Special Grant in the Chemical Sciences, 2011
Regents’ Outstanding Teaching Award, 2010
College of Natural Sciences Teaching Excellence Award, 2010
CDMRP Fellowship Award, Memorial Sloan-Kettering, 2005-2007
Upjohn-Pharmacia Fellow, California Institute of Technology, 1998
Institute Fellowship, California Institute of Technology, 1997-1998
Institute for Cellular and Molecular Biology
Natural Product Synthesis and Regenerative Science
The study of natural products with regenerative properties is the focus of our group. Within the field of small molecule mediated regenerative science there are two primary areas of inquiry; target-oriented synthesis and chemical biology. In addition to their related biological activities, small molecule are selected based on their limited supply from natural sources and structures that, from a synthetic chemistry point of view, have atom connectively challenges. Using small molecules prepared in our laboratory we develop an understanding of how to improve biological performance and/or investigate the mechanism(s) of action. Information gained through these studies, as well as through collaborations, determine the future direction of the projects. Models used to study the effect of the small molecules include primary neuronal culture and C. elegans.
C. Yuan, Y. Liang, T. M. Hernandez, A. Berriochoa, K. N. Houk, D. Siegel “Metal-Free Aromatic C-H Oxidation Through a Reverse Rebound Mechanism.” Nature 2013, 499, 192-196.
A. Axelrod, A. M. Eliasen, M. R. Chin, K. Zlotkowski, D. Siegel “Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration.” Angew. Chem. Int. Ed. 2013, 52, 3421-3424.