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Contact Information

Office: NHB 5.358A
Phone: 512-232-8220

Lab

Office: NHB 5.350
Phone: 512-471-4232

Guangbin Dong

gbdong@cm.utexas.edu


Research Group

Dong Group



Education

BS, Peking University, 2003

PhD, Stanford University, 2009

 

Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, 2011



Awards

Searle Scholar (2013)
National Science Foundation CAREER Award (2013-2018)

Thieme Synlett/Synthesis Journal Award (2012)

Chemistry and Molecularly Targeted Therapeutic Development Award, Center for Targeted Therapy (CTT) & Texas Institute for Drug & Diagnostic Development (TI-3D) (2012)

Ralph E. Powe Junior Faculty Enhancement Awards (2012)

Herman Frasch Foundation Award in Chemical Research (2012-2017)

Rom Rhome International Travel Award (2011)

CPRIT Award for Recruitment First-Time Tenure-Track Faculty Member (2011)

Reaxys Travel Award (2011)

IUPAC Prizes for Young Chemists, IUPAC (2010)

Reaxys PhD Prize, Runners-up, Elsevier (2010)

Camille and Henry Dreyfus Environmental Chemistry Fellow (2009)

Beckman Postdoctoral Fellowship, Finalist (2009)

American Chemical Society (ACS) Travel Awards for Graduate Students, Division of Organic Chemistry (2009)

Chinese Government Award for Outstanding Self-Financed Students Abroad (2008-2009)

Larry Yung Stanford Graduate Fellowship in Science and Engineering, Stanford University (2006-2009)

Samsung Fellowship, Peking University (2001-2002)

Youlong Fellowship, Peking University (2000-2001)

Dupont Fellowship, Peking University (1999-2000)



Catalytic Reaction Development, Organometallic Chemistry, Natural Product Total Synthesis

 

Our research focuses on 1) developing new transition metal catalysts based on supermolecular chemistry for chemoselective C-H bond activation of small molecules; 2) developing novel catalytic C-H and C-C bond activation methods for efficient small-molecule agents synthesis; 3) establishing efficient synthetic routes to access natural products with high potent anticancer activity and their unnatural analogues; and 4) evaluating in vitro and in vivo efficacy of rationally designed natural product analogues and understanding the origins of the selectivity in the cell-killing process.

One of our research goals is to harness the power of transition-metal catalysts to ease the discovery of new cancer therapeutics and ultimately address the pressing needs in the development of anti-cancer drug.



Representative Publications

Wang, Zhiqian; Reinus, Brandon J.; Dong, Guangbin* “Catalytic Regioselective C-Alkylation of 1,2-Diketones Using simple olefins: A Traceless/Recyclable Directing Group Strategy” Journal of the American Chemical Society, 2012, 134, 13954–13957.

 

Xu, Tao; Dong, Guangbin* “Rh-Catalyzed Lewis Acid-Promoted Regioselective Carboacylation of Olefins: A C–C Activation Approach to Access Fused-Ring Systems” Angew. Chem. Int. Ed., 2012, 51, 7567–7571.

 

Xu, Tao; Ko, Haye Min; Savage, Nik; Dong, Guangbin* “Highly Enantioselective Rh-Catalyzed Carboacylation of Olefins: Efficient Syntheses of Chiral Poly-Fused Rings” Journal of the American Chemical Society, 2012, 134, in press.

 

Ren, Zhi; Mo, Fanyang; Dong, Guangbin* “Catalytic Functionalization of Unactivated sp3 C–H Bonds via exo-Directing Group: Synthesis of Chemically Differentiated 1,2-Diols” Journal of the American Chemical Society, 2012, 134, 16991-16994.

 

Mo, Fanyang; Trzepkowski, Louis; Dong, Guangbin* “Synthesis of ortho-Acylphenols via Pd-Catalyzed Ketone-Directed Hydroxylation of Arenes” Angew. Chem. Int. Ed., 2012, 51,13075-13079

 

Dong, Guangbin; Teo, Peili; Wickens, Zachary, K.; Grubbs, Robert H.* “Primary Alcohols from Terminal Olefins: Formal Anti-Markovnikov Hydration-like Process via Triple Relay Catalysis” Science, 2011, 333, 1609-1612.

 

Trost, Barry M.;* Dong, Guangbin “Total Synthesis of Bryostatin 16 Using Atom Economical and Chemoselective Approaches.” Nature, 2008, 456, 485-488.