Contact Information

Office: NHB 5.358A
Phone: 512-232-8220


Office: NHB 5.350
Phone: 512-471-4232

Guangbin Dong

Research Group

Dong Group


BS, Peking University, 2003
PhD, Stanford University, 2009
Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, 2011


  • Amgen Young Investigator Award (2014)
  • Biomatik Distinguished Junior Faculty Award (2014)
  • DuPont's 2014 Class of Young Professors (2014)
  • Sloan Research Fellowship (2014)
  • Searle Scholar (2013)
  • National Science Foundation CAREER Award (2013-2018)
  • Thieme Synlett/Synthesis Journal Award (2012)
  • Chemistry and Molecularly Targeted Therapeutic Development Award, Center for Targeted Therapy (CTT) & Texas Institute for Drug & Diagnostic Development (TI-3D) (2012)
  • Ralph E. Powe Junior Faculty Enhancement Awards (2012)
  • Herman Frasch Foundation Award in Chemical Research (2012-2017)
  • Rom Rhome International Travel Award (2011)
  • CPRIT Award for Recruitment First-Time Tenure-Track Faculty Member (2011)
  • Reaxys Travel Award (2011)
  • IUPAC Prizes for Young Chemists, IUPAC (2010)
  • Reaxys PhD Prize, Runners-up, Elsevier (2010)
  • Camille and Henry Dreyfus Environmental Chemistry Fellow (2009)
  • Beckman Postdoctoral Fellowship, Finalist (2009)
  • American Chemical Society (ACS) Travel Awards for Graduate Students, Division of Organic Chemistry (2009)
  • Chinese Government Award for Outstanding Self-Financed Students Abroad (2008-2009)
  • Larry Yung Stanford Graduate Fellowship in Science and Engineering, Stanford University (2006-2009)
  • Samsung Fellowship, Peking University (2001-2002)
  • Youlong Fellowship, Peking University (2000-2001)
  • Dupont Fellowship, Peking University (1999-2000)

Catalytic Reaction Development, Organometallic Chemistry, Natural Product Total Synthesis


Our research focuses on 1) developing new transition metal catalysts based on supermolecular chemistry for chemoselective C-H bond activation of small molecules; 2) developing novel catalytic C-H and C-C bond activation methods for efficient small-molecule agents synthesis; 3) establishing efficient synthetic routes to access natural products with high potent anticancer activity and their unnatural analogues; and 4) evaluating in vitro and in vivo efficacy of rationally designed natural product analogues and understanding the origins of the selectivity in the cell-killing process.

One of our research goals is to harness the power of transition-metal catalysts to ease the discovery of new cancer therapeutics and ultimately address the pressing needs in the development of anti-cancer drug.

Representative Publications

Dong, Z.; Wang, J.; Dong, G.* “Simple Amine-Directed meta-Selective C–H Arylation via Pd/Norbornene Catalysis.” J. Am. Chem. Soc., 2015, 137, 5887-5890.



Dermenci, A.; Whittaker, R. E.; Gao, Y.; Cruz, F.; Yu, Z.*; Dong, G.* “Rh-Catalyzed Decarbonylation of Conjugated Ynones via Carbon-Alkyne Bond Activation: Reaction Scope and Mechanistic Exploration via DFT Calculations.” Chem. Sci., 2015, 6, 3201-3210.



Zeng, R.; Dong, G.* “Rh-Catalyzed Decarbonylative Cycloaddition with Alkynes via C–C Activation of Isatins.” J. Am. Chem. Soc., 2015, 137, 1408-1411.



Xu, T.; Dong, G.* “Coupling of Sterically Hindered Trisubstituted Olefins and Benzocyclobutenones by C–C Activation: Total Synthesis and Structural Revision of Cycloinumakiol.” Angew. Chem., Int. Ed., 2014, 53, 10733-10736.



Ko, H. M.; Dong, G.* “Cooperative Activation of Cyclobutanones and Olefins Leads to Bridged Ring Systems by a Catalytic [4 + 2] Coupling.” Nature Chem., 2014, 6, 739-744.



Mo, F.; Dong, G.* “Regioselective Ketone α-Alkylation with Simple Olefins via Dual Activation.” Science, 2014, 345, 68-72.



Huang, Z.; Dong, G.* “Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides” J. Am. Chem. Soc., 2013, 135, 17747-17750.



Ren, Z.;Mo, F.;Dong, G.* “Catalytic Functionalization of Unactivated sp3 C–H Bonds via exo-Directing Groups: Synthesis of Chemically Differentiated 1,2-Diols.” J. Am. Chem. Soc., 2012, 134, 16991-16994.