Guangbin Dong

gbdong@cm.utexas.edu

Research Group

Dong Group

Education

BS, Peking University, 2003

PhD, Stanford University, 2009

 

Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, 2011

Awards

CPRIT Award for Recruitment of First-Time, Tenure-Track Faculty Members, 2011

Reaxys PhD Club Travel Awards, 2011

IUPAC Prizes for Young Chemists, IUPAC, 2010

Reaxys PhD Prize, Runners-up Award, Elsevier, 2010

Camille and Henry Dreyfus Environmental Chemistry Fellow, 2009

American Chemical Society (ACS) Travel Awards for Graduate Students, Division of Organic Chemistry, 2009

Chinese Government Award for Outstanding Self-Financed Students Abroad, 2009

Larry Yung Stanford Graduate Fellowship in Science and Engineering, Stanford University, 2006-09

Samsung Fellowship, Peking University, 2002

Youlong Fellowship, Peking University, 2001 Dupont Fellowship, Peking University, 2000

Catalytic Reaction Development, Organometallic Chemistry, Natural Product Total Synthesis

 

Our research focuses on 1) developing new transition metal catalysts based on supermolecular chemistry for chemoselective C-H bond activation of small molecules; 2) developing novel catalytic C-H and C-C bond activation methods for efficient small-molecule agents synthesis; 3) establishing efficient synthetic routes to access natural products with high potent anticancer activity and their unnatural analogues; and 4) evaluating in vitro and in vivo efficacy of rationally designed natural product analogues and understanding the origins of the selectivity in the cell-killing process.

One of our research goals is to harness the power of transition-metal catalysts to ease the discovery of new cancer therapeutics and ultimately address the pressing needs in the development of anti-cancer drug.

Representative Publications

Dong, Guangbin; Teo, Peili; Wickens, Zachary, K.; Grubbs, Robert H. “Direct Synthesis of Primary Alcohols from Non-activated Terminal Olefins: A Catalytic Anti-Markovnikov Hydration-like Process Using a Triple Relay Catalysis System” Science, submitted.

 

Dong, Guangbin; Wickens, Zachary, K.; Grubbs, Robert H. “Mn-catalyzed dihydroxylation of 1,1-disubstituted olefins using air as the solo oxidant and water as the solvent” Manuscript in preparation.

 

Trost, Barry M.; Dong, Guangbin “Total Synthesis of Bryostatin 16 using a Pd-Catalyzed Diyne-coupling as Macrocyclization Method and Synthesis of C20-epi-Bryostatin 7 as a Potent Anticancer Agent” Journal of the American Chemical Society, 2010, 132, 16403–16416.

 

Dong, Guangbin “A Historical Story on the Synthesis of Agelastatin” Pure and Applied Chemistry, 2010, 82, 2231-2246 (2010 IUPAC Prize for Young Chemists, invited review).

 

Trost, Barry M.; Dong, Guangbin “Asymmetric Annulation toward Pyrrolo-piperazinones. Concise Enantioselective Syntheses of Pyrrole Alkaloid Natural Products.” Organic Letters, 2007, 9, 2357-2359.

 

Trost, Barry M.; Dong, Guangbin “Total Synthesis of Bryostatin 16 Using Atom Economical and Chemoselective Approaches.” Nature, 2008, 456, 485-488. Highlighted by Angewandte Chemie International Edition (2009, 48, 3221-3223), Chemical and Engineering News (2008, 8, 11), Chemistry Worldof Royal Chemical Society (2008, 27 November) and Nature (2008, 456, 451-453.)

 

Trost, Barry M.; Dong, Guangbin; Vance, Jennifer A. “A Diosphenol-Based Strategy for the Total Synthesis of (–)-Terpestacin.” Journal of the American Chemical Society, 2007, 129, 4540-4541.

 

Trost, Barry M.; Dong, Guangbin “New Class of Nucleophiles for Palladium-Catalyzed Asymmetric Allylic Alkylation. Total Synthesis of Agelastatin A.” Journal of the American Chemical Society, 2006, 128, 6054-6055.