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Contact Information

Office: WEL: 3.426
Phone: 512-232-1454

Lab

Office: WEL 3.246
Phone: 512-232-1994

Jason B. Shear

jshear@cm.utexas.edu

Professor, Faculty



Research Group

Shear Labs



Education

BS, University of Texas - Austin, 1989
PhD, Howard Hughes Predoctoral Fellow, Stanford University, 1995

NSF Postdoctoral Fellow, Cornell University (1994-1996)



Awards

ACS Arthur F. Findeis Award in Analytical Chemistry, 2005
Beckman Scholars Advisory Panel, 2004
Research noted as a Chemical Development of the Year by C&E News, 2003
Eli Lilly Grantee in Analytical Chemistry, 2000
Alfred P. Sloan Research Fellowship, 1999
Top 100 Young Innovator citation, MIT Technology Review, 1999
Searle Scholars Award, Kinship Foundation, 1998
Beckman Foundation Young Investigator Award, 1997



Affiliations

Beckman Center for the Design and Fabrication of Sensor Arrays; Institute for Neuroscience; Institute for Cellular and Molecular Biology; Center for Nano- and Molecular Science and Technology; Waggoner Center for Alcohol & Addiction Research; IGERT: Optical Biomedical Engineering; Texas Materials Institute



Research

 

Our research focuses on the design of new strategies for investigating chemical and biological processes on defined, small communities of living cells. Toward this aim, we have developed laser-based methods for creating 3D-printed microscopic enclosures using biological materials for physically confining small numbers of cells, where their behaviors and chemical properties can be tracked as they undergo division, development, and interactions within small communities. This highly collaborative work is often undertaken in concert with other research laboratories distributed across various scientific and engineering areas of specialization. Current areas of interest including characterizing the nature of bacterial social behaviors and interactions between micro-organisms and immunological cell types, investigations on characteristics of metastatic cells, and development of novel methodologies in 3D printing and imprinting of biologically relevant materials.   



Representative Publications

 

"3D-Printed Microfluidic Microdissector for High-Throughput Studies of Cellular Aging," Eric C. Spivey, Blerta Xhemalce, Jason B. Shear, and Ilya J. Finkelstein, Anal. Chem., 2014, vol. 86, 7406–7412.

 

"Oxygen limitation within a bacterial aggregate," A. K. Wessel, T. Arshad, M. Fitzpatrick, J. L. Connell, R. Bonnecaze, J. B. Shear, and M. Whiteley, MBio, 2014, vol. 5, e00992-14.

 

"Real-time monitoring of quorum sensing in 3D-printed bacterial aggregates using scanning electrochemical microscopy," Jodi L. Connell, Jiyeon Kim, Allen J. Bard, Jason B. Shear, and Marvin Whiteley. Proc. Natl. Acad. Sci. USA, 2014, vol. 111, 18255-18260.

 

“3D Printing of Microscopic Bacterial Communities," J. L. Connell, E. T. Ritschdorff, M. Whiteley, and J. B. Shear, Proc. Natl. Acad. Sci. USA, 2013, vol. 110, 18380–18385.

 

“Sociomicrobiology in engineered landscapes,” J. L. Connell, M. Whiteley, and J. B. Shear, Nature Chemical Biology, 2012, vol. 8, 10–13.